This guide is focus on using robots like an innovative tool to enhance students’ motivation towards the study of ESTEAM subjects, improve their basic and transversal skills, art design and promote gender equality. The guide contain: A Robotics Multidisciplinary Educational Framework involving the robotic systems, based on the following steps: 1. The construction of the robot 2. Programming the robot 3. Learning of content based on hands-on experiences 4. Methodology for teaching ESTEAM in I-VET schools using robots to involve I-VET students in the learning process, to develop transversal skills (i.e., creativity, innovative and crtiical thinking, problem solving, team working, resilience, self-confidence, etc.), to integrate women and promote gender equality in ESTEAM subjects. 5. Effective use of robots and transnational cooperation to promote the ESTEAM knowledge.